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Hybrid coronary revascularization is an innovative approach to treating coronary artery disease, combining elements of both surgical and percutaneous interventions to improve blood flow to the heart. This technique typically involves a surgical procedure, such as coronary artery bypass grafting (CABG), paired with percutaneous coronary intervention (PCI), which may include balloon angioplasty and stent placement. The primary goal of hybrid revascularization is to leverage the benefits of both methods, optimizing outcomes for patients with complex coronary disease. By surgically bypassing significant blockages in larger coronary arteries while simultaneously addressing smaller lesions with catheter-based techniques, this method aims to provide a more comprehensive solution. Patients might be ideal candidates for hybrid revascularization if they present with multi-vessel disease or if their anatomical situation suggests that a combined strategy would be more effective than relying on one modality alone. One significant advantage of this approach is the potential for improved ischemic relief and better quality of life when compared to traditional therapies. The combination of CABG and PCI is designed to maximize the benefits each procedure offers while mitigating their individual limitations. Moreover, hybrid revascularization can lead to reduced recovery times, lower rates of complications, and shorter hospital stays, which are essential considerations for both patients and healthcare systems. The selection of candidates for hybrid revascularization typically involves a thorough evaluation by a multidisciplinary team, including cardiologists and cardiac surgeons, who assess the appropriateness of the procedure based on the patient's overall health, coronary anatomy, and individual preferences. Recent studies have indicated that hybrid coronary revascularization may result in similar or even superior long-term outcomes when compared to conventional treatments, particularly for specific subsets of patients, such as those with left main coronary disease or those who are not suitable for complete surgical revascularization alone. Furthermore, the development and refinement of hybrid operating rooms, equipped for both surgical and interventional procedures, have facilitated this approach, allowing for smoother transitions between the two types of interventions and potentially enhancing patient safety. As the field of cardiovascular medicine continues to evolve, the role of hybrid revascularization is likely to expand, offering new insights and possibilities in the management of coronary artery disease. Continuous research and clinical trials are essential to fully understand the long-term efficacy and safety of this method compared to traditional approaches. The integration of hybrid techniques into clinical practice reflects a broader trend toward personalized medicine, where treatment strategies are tailored to individual patients' needs, thereby optimizing care and improving outcomes in the management of heart disease. Thus, hybrid coronary revascularization represents a significant advancement in cardiovascular therapy, addressing the complexities of coronary artery disease with a multifaceted and patient-centered approach.